Fluorescent probes for hydrogen sulfide detection and bioimaging

Area of Science:

• Biomedical Engineering
• Chemical Biology
• Molecular Imaging

Background:

• Fluorescence bioimaging offers high spatial-temporal resolution for intracellular detection.
• Hydrogen sulfide (H2S) is a crucial signaling gasotransmitter involved in cellular processes.
• Development of specific fluorescent probes is essential for H2S research.

Purpose of the Study:

• To review synthesis and design strategies for fluorescent probes targeting H2S.
• To highlight probes for detecting other reactive sulfur species.
• To facilitate understanding of H2S physiological and pathological roles.

Main Methods:

• Analysis of reaction-based mechanisms for probe design.
• Review of recent advancements in fluorescent probe development for H2S.
• Inclusion of probes for sulfane sulfurs and SO2 derivatives.

Main Results:

• Numerous fluorescent probes for H2S detection have been developed.
• These probes allow for non-invasive monitoring of H2S in native environments.
• Strategies focus on reaction types between H2S and probe molecules.

Conclusions:

• Fluorescent probes are vital tools for investigating H2S signaling.
• Advanced probe design enhances specificity and sensitivity for sulfur species detection.
• This research supports deeper understanding of cellular redox and signaling pathways.