Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genetic biomarkers of clinical manifestations in giant cell arteritis define distinct patient subgroups.

Annals of the rheumatic diseases·2026

Same author

Prevalence and Recovery of Arrhythmia-Induced Cardiomyopathy in Patients With Newly Diagnosed Heart Failure Using a Wearable Defibrillator: A Real-World Cohort Study.

Journal of cardiovascular electrophysiology·2026

Same author

[Orbital pathology, not always caused by endocrine factors].

Praxis·2026

Same author

Current management of eosinophilic granulomatosis with polyangiitis across Europe: insights from a multinational expert survey.

Rheumatology (Oxford, England)·2026

Same author

First profiling of the national Swiss Clinical Quality Management giant cell arteritis and polymyalgia rheumatica registry.

Clinical and experimental rheumatology·2026

Same author

Comparative 1-year outcomes of pentaspline versus circular array pulsed field ablation for pulmonary vein isolation with adjunctive atrial lines.

Heart rhythm·2026

Same journal

Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential.

Experimental biology and medicine (Maywood, N.J.)·2026

Same journal

Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form <i>Trypanosoma brucei brucei</i>.

Experimental biology and medicine (Maywood, N.J.)·2026

Same journal

High systolic blood pressure and stroke: evidence from the NHANES 1999-2023 and global burden of disease 2021.

Experimental biology and medicine (Maywood, N.J.)·2026

Same journal

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform.

Experimental biology and medicine (Maywood, N.J.)·2026

Same journal

Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox.

Experimental biology and medicine (Maywood, N.J.)·2026

Same journal

Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis.

Experimental biology and medicine (Maywood, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 26, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Tissue-engineered microenvironment systems for modeling human vasculature.

Anna Tourovskaia¹, Mark Fauver¹, Gregory Kramer¹

¹Nortis, Inc., Seattle, WA 98195, USA.

Experimental Biology and Medicine (Maywood, N.J.)

|July 18, 2014

Summary

This summary is machine-generated.

Researchers developed a microfluidic chip to create tissue-engineered microenvironment systems (TEMS) that better model human vascularized tissues. This novel in vitro system aids in predicting drug efficacy and disease progression more accurately.

Keywords:

Microfluidic device body-on-chip microenvironment microphysiological system microvasculature organ-on-chip tissue engineering

More Related Videos

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Related Experiment Videos

Last Updated: Apr 26, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Area of Science:

Biotechnology
Biomaterials Engineering
Vascular Biology

Background:

High attrition rates in drug development necessitate improved in vitro models.
Conventional 2D cultures and animal models have limitations in predicting clinical outcomes.
3D cell arrangements, co-cultures, and physico-chemical cues enhance predictive power of in vitro systems.

Purpose of the Study:

To develop a microfluidic chip for creating tissue-engineered microenvironment systems (TEMS).
To engineer perfusable tubular tissue structures that mimic human microvasculature.
To provide a tool for modeling vascularized human tissue microenvironments in vitro.

Main Methods:

Designed a microfluidic chip with a chamber for extracellular matrix (ECM) and tubular channels.
Seeded endothelial cells (ECs) into channels to form perfusable tubular tissue structures.
Connected engineered tissues to fluidic channels for perfusion.

Main Results:

Successfully created models of angiogenesis, blood-brain barrier (BBB), and tumor-cell extravasation.
Angiogenesis model demonstrated true sprouting in response to growth factor gradients.
BBB model incorporated brain-specific ECs, astrocytes, and pericytes.
Tumor-cell extravasation model allowed visualization and measurement of tumor cell migration.

Conclusions:

The developed microfluidic chip technology enables the creation of TEMS.
These TEMS recapitulate structural, functional, and physico-chemical aspects of vascularized human tissues.
The technology offers a promising tool for in vitro drug development and disease modeling.