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Published on: December 23, 2022
First isolate of KPC-2-producing Klebsiella pneumonaie sequence type 23 from the Americas
Daniela Cejas1, Liliana Fernández Canigia2, Giovanna Rincón Cruz3
1Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
Abstract:
KPC-2-producing Klebsiella pneumoniae isolates mainly correspond to clonal complex 258 (CC258); however, we describe KPC-2-producing K. pneumoniae isolates belonging to invasive sequence type 23 (ST23). KPC-2 has scarcely been reported to occur in ST23, and this report describes the first isolation of this pathogen in the Americas. Acquisition of resistant markers in virulent clones could mark an evolutionary step toward the establishment of these clones as major nosocomial pathogens.
Insights
This study identifies Klebsiella pneumoniae producing KPC-2 carbapenemase in sequence type 23 (ST23), a rare occurrence. This marks the first detection of this resistant pathogen in the Americas, potentially signaling a new threat in hospitals.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae are a significant global health concern.
- Most KPC-2-producing isolates belong to clonal complex 258 (CC258).
- The emergence of KPC-2 in other sequence types (STs) is not well-documented.
