Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

29
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
29
Dementia01:30

Dementia

685
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
685
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

19
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
19
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

750
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
750
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.7K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SARS-CoV-2 Infection, Vaccination Status, and Dementia Risk: A Nested Case-Control Study.

Influenza and other respiratory viruses·2026
Same author

High ambient temperature, humidity, heat index, and stroke risk in a Mediterranean region.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Apr 26, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

7.4K

Circulating biomarkers that predict incident dementia.

Galit Weinstein1, Sudha Seshadri1

  • 1Department of Neurology, Boston University School of Medicine, B602, 72 East Concord Street, Boston, MA 02118, USA ; Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA.

Alzheimer'S Research & Therapy
|July 18, 2014
PubMed
Summary

Early detection of dementia risk is crucial. Circulating biomarkers offer a less invasive and cost-effective method for identifying individuals at risk for dementia, particularly Alzheimer's disease.

More Related Videos

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

36.6K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.1K

Related Experiment Videos

Last Updated: Apr 26, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

7.4K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

36.6K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.1K

Area of Science:

  • Neuroscience
  • Biomarkers
  • Preventive Medicine

Background:

  • Current dementia diagnosis relies on clinical symptoms, often after significant brain damage has occurred, limiting intervention effectiveness.
  • Early detection of dementia risk is vital for public health and preventive strategies.
  • Alzheimer's disease is a leading cause of dementia, necessitating early diagnostic tools.

Purpose of the Study:

  • To review candidate circulating biomarkers for early detection of dementia risk.
  • To identify molecules that predict the development of dementia, specifically Alzheimer's disease.
  • To highlight the advantages of circulating biomarkers for large-scale screening.

Main Methods:

  • Review of scientific literature on candidate molecules for dementia risk prediction.
  • Focus on circulating biomarkers suitable for primary care settings.
  • Analysis of markers related to vascular injury, metabolic and inflammatory states, amyloid and tau pathways, and neural degeneration.

Main Results:

  • Circulating biomarkers are less invasive, costly, and more accessible than lumbar puncture or brain imaging for dementia screening.
  • Candidate molecules include markers of vascular, metabolic, inflammatory, amyloid, and tau pathways.
  • Measures of neural degeneration and repair efforts are also being investigated as predictors.

Conclusions:

  • Circulating biomarkers hold significant promise for the early detection of dementia risk.
  • Accessible and non-invasive biomarkers are essential for effective large-scale screening and timely intervention.
  • Further research into these candidate molecules can improve dementia prevention and management strategies.