Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of local control on widespread progression and survival in oligometastasis-directed SBRT: Results from a large international database.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2023
Same author

Correction to: Re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis.

Journal of neuro-oncology·2023
Same author

Quantifying uncertainties associated with reference dosimetry in an MR-Linac.

Journal of applied clinical medical physics·2023
Same author

In Reply to Sari et al.

International journal of radiation oncology, biology, physics·2023
Same author

Re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis.

Journal of neuro-oncology·2023
Same author

ACR Appropriateness Criteria® Management of Vertebral Compression Fractures: 2022 Update.

Journal of the American College of Radiology : JACR·2023

Related Experiment Video

Updated: Apr 26, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

13.9K

Stereotactic radiosurgery for multiple brain metastases.

Tai-Chung Lam1, Arjun Sahgal, Eric L Chang

  • 1Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Expert Review of Anticancer Therapy
|July 19, 2014
PubMed
Summary

Stereotactic radiosurgery (SRS) is effective for multiple brain metastases (≥ 4 tumors), offering similar survival to fewer lesions. This review summarizes evidence on SRS for numerous brain metastases, including technical aspects and cost-effectiveness.

Keywords:
brain metastasesgamma knife systemneurocognitive functionstereotactic radiosurgerywhole brain radiation therapy

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

22.0K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.2K

Related Experiment Videos

Last Updated: Apr 26, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

13.9K
Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

22.0K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.2K

Area of Science:

  • Oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Whole brain radiation therapy (WBRT) has known neurocognitive and quality-of-life detriments.
  • Randomized trials show no survival benefit from adding WBRT to stereotactic radiosurgery (SRS) for limited metastases.
  • The role of SRS for multiple brain metastases (≥ 4 tumors) is debated.

Purpose of the Study:

  • To review current evidence on SRS for multiple brain metastases (2-3 vs. ≥ 4 lesions).
  • To summarize technical aspects of SRS for brain metastases.
  • To evaluate the cost-effectiveness of SRS in this context.

Main Methods:

  • Literature review of studies on SRS for brain metastases.
  • Analysis of evidence stratified by tumor burden (limited vs. multiple lesions).
  • Inclusion of technical considerations and economic evaluations.

Main Results:

  • Emerging evidence suggests local control with SRS is independent of metastasis number.
  • Patients with ≥ 4 brain metastases show similar overall survival to those with 2-4 tumors.
  • Data on technical aspects and cost-effectiveness are presented.

Conclusions:

  • SRS is a viable option for patients with multiple brain metastases.
  • The number of metastases does not appear to significantly impact local control or overall survival with SRS.
  • Further research into technical and cost-effectiveness aspects is warranted.