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Factors affecting the duration of phase I of dexamethasone - cyclophosphamide pulse therapy
Chitra S Nayak1, Somshukla Ray, Anil Thombre
1Department of Dermatology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai Central, Mumbai, India.
Background:
The introduction of dexamethasone-cyclophosphamide pulse (DCP) therapy for the pemphigus group of disorders by Pasricha has revolutionized the therapy for pemphigus. There are very few studies regarding factors affecting duration of phase I of the DCP.
Aims:
Our purpose was to study the relationship between various factors and duration of the phase I.
Methods:
A retrospective study of 98 patients of pemphigus on Dexamethasone Pulse therapy was conducted. Patients were classified according to duration of Phase 1 as those with phase I less than 6 months and those more than 6 months and analyzed for variable factors affecting duration of phase I.
Results:
Disease severity in pemphigus significantly prolonged the duration of phase I of DCP. Longer duration was also observed in patients on concurrent oral steroid therapy (both statistically significant).
Conclusion:
The findings from our study help us to address patient expectations and apprehensions regarding duration of therapy. A detailed understanding of the various patient and disease related factors responsible for affecting Phase I duration will help in better management of the patient, and the disease.
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