Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 26, 2026

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

10.9K

A microfluidic device to sort capsules by deformability: a numerical study.

Lailai Zhu1, Cecilia Rorai, Dhrubaditya Mitra

  • 1Linné Flow Centre and SeRC (Swedish e-Science Research Centre), KTH Mechanics, 10044 Stockholm, Sweden. lailai@mech.kth.se.

Soft Matter
|July 19, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometry-programmed self-wrinkling in organo-hydrogels for anisotropic mechanics and adaptive sensing.

Nature communications·2026
Same author

Chemotactic navigation in robotic swimmers via reset-free hierarchical reinforcement learning.

Nature communications·2025
Same author

Sheathless Elasto-Inertial Focusing of Sub-25 Nm Particles in Straight Microchannels.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Vertical transport of buoyant microplastic particles in the ocean: The role of turbulence and biofouling.

Environmental pollution (Barking, Essex : 1987)·2025
Same author

Imaging-guided bioresorbable acoustic hydrogel microrobots.

Science robotics·2024
Same journal

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments.

Soft matter·2026
Same journal

Catanionics from biosurfactants and regular surfactants: miscibility and structure.

Soft matter·2026
Same journal

Adhesives with a thickness smaller than the fractocohesive length enhance adhesion.

Soft matter·2026
Same journal

Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies.

Soft matter·2026
Same journal

Effects of methoxy substituents on self-assembly and gelation performance of benzamide-based organogelators.

Soft matter·2026
Same journal

Rheology of <i>Escherichia coli</i> suspensions with various bacterial morphologies and motion characteristics.

Soft matter·2026
See all related articles

This study introduces a novel microfluidic device for sorting elastic capsules based on deformability. Numerical simulations show the device is robust to variations in capsule position and obstacle shape, enhancing cell sorting capabilities.

Area of Science:

  • Biophysics
  • Microfluidics
  • Computational Science

Background:

  • Cell sorting is crucial in biological research and diagnostics.
  • Existing microfluidic methods face challenges in efficiency and robustness.

Purpose of the Study:

  • To propose and numerically investigate a novel microfluidic device for sorting elastic capsules by deformability.
  • To assess the device's performance under various conditions and geometric modifications.

Main Methods:

  • Extensive numerical simulations were employed to design and analyze the microfluidic device.
  • The device design includes a duct with a semi-cylindrical obstacle and a diffuser.

Main Results:

  • The proposed microfluidic device effectively sorts elastic capsules based on their deformability.

More Related Videos

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

7.7K
Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics
06:03

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

962

Related Experiment Videos

Last Updated: Apr 26, 2026

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

10.9K
Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

7.7K
Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics
06:03

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

962
  • Device performance is robust to changes in initial capsule position and minor alterations in obstacle shape.
  • Increased confinement perpendicular to the device plane enhances sorting efficiency.

    • Conclusions:

    • This work presents the first numerical study of cell sorting using a realistic microfluidic device.
    • The developed device offers a promising approach for label-free cell separation based on mechanical properties.