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γ-Secretase: a horseshoe structure brings good luck

Michael S Wolfe1, Dennis J Selkoe1

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Cell
|July 19, 2014
PubMed
Summary

The intramembrane protease gamma-secretase (γ-secretase) structure reveals a horseshoe shape, aiding substrate recognition. This breakthrough advances understanding of its role in cell signaling and Alzheimer's disease research.

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