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Updated: Apr 26, 2026

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
Published on: May 22, 2020
Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1
Won Hee Jang1, Sun Hee Choi, Joo Young Jeong
1a Department of Biochemistry and u-HARC, College of Medicine , Inje University , Busan , Korea.
Abstract:
Location of membrane proteins is often stabilized by PDZ domain-containing scaffolding proteins. Using the yeast two-hybrid screening, we found that neurexin 1 interacted with multi-PDZ domain protein 1 (MUPP1) through PDZ domain. Neurexin 2 and 3 also interacted with MUPP1. MUPP1 and neurexin 1 were co-localized in cultured cells. These results suggest a novel mechanism for localizing neurexin 1 to synaptic sites.
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