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Nanomedicine based nanoparticles for neurological disorders
Bhasker Sriramoju, Rupinder K Kanwar, Jagat R Kanwar1
1Nanomedicine- Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, Australia. jagat.kanwar@deakin.edu.au.
Current Medicinal Chemistry
|July 22, 2014
Summary
Nanotechnology offers novel drug delivery systems to overcome the blood-brain barrier for neurological disorders. Smart nanosystems show promise for targeted brain therapies, but long-term toxicity requires further study.
Area of Science:
- Neurology
- Nanotechnology
- Drug Delivery
Background:
- Neurological disorders like Alzheimer's and Parkinson's significantly impact human health.
- The blood-brain barrier restricts conventional drug access, limiting therapeutic efficacy.
- Novel drug delivery systems are crucial for maintaining therapeutic drug levels in the brain.
Purpose of the Study:
- To review the applications of nanotechnology in treating neurological disorders.
- To highlight the potential of nanodelivery systems in overcoming the blood-brain barrier.
- To discuss the development of smart nanosystems for theranostic applications.
Main Methods:
- Review of current literature on nanotechnology in neurological disorder treatment.
- Analysis of nanodelivery systems' ability to cross the blood-brain barrier.
- Discussion of "smart" nanosystems for targeted drug delivery.
Main Results:
- Nanodelivery systems demonstrate potential in crossing the blood-brain barrier and reaching brain tissues.
- Smart nanosystems offer tailored surfaces for effective theranostic delivery.
- Existing nanotechnologies have partially addressed drug delivery challenges for neurological conditions.
Conclusions:
- Nanotechnology presents a promising approach for improved drug delivery in neurological disorders.
- Further research is essential to understand long-term nanoformulation toxicities and neuropathology.
- Smart nanosystems represent a significant advancement in theranostic delivery for brain diseases.
