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Updated: Apr 26, 2026
04:09
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
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Effects of a hydrogel patch on denture-related traumatic ulcers; an exploratory study
Anca Jivanescu1, Wenche Sylling Borgnakke, Luciana Goguta
1Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, University of Medicine and Pharmacy "Victor Babes,", Timisoara, Romania.
Summary
Hydrogel patches significantly accelerated healing and reduced pain for denture-related oral lesions. This novel treatment shows promise for edentulous individuals, including those with type 2 diabetes.
Area of Science:
- Oral Medicine
- Wound Healing
- Biomaterials
Background:
- Denture-related oral mucosal lesions are common in edentulous individuals.
- These lesions can cause significant pain and affect denture wear.
- Effective management strategies are needed to promote healing and alleviate discomfort.
Purpose of the Study:
- To evaluate the efficacy of hydrogel patch wound dressing.
- To assess the impact on healing time of denture-related oral lesions.
- To determine the effect on pain levels associated with these lesions.
Main Methods:
- An exploratory study involving 23 adults with complete dentures and related ulcerative lesions.
- Lesions were treated with either usual care (denture adjustment) or usual care plus hydrogel patch application.
- Healing and pain levels were monitored over 7 days.
Main Results:
- Hydrogel patch treatment showed greater reduction in lesion size compared to usual care alone.
- Significant pain reduction was reported by 65% of participants using hydrogel patches versus 30% with usual care.
- Healing rates were comparable between participants with and without diabetes.
Conclusions:
- Hydrogel patches may offer a novel and effective treatment for denture-related oral mucosal lesions.
- This approach shows potential for accelerating healing and reducing pain, even in patients with type 2 diabetes.
- Larger studies are recommended to confirm these preliminary findings.
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