Relative lens vault in subjects with angle closure

Area of Science:

• Ophthalmology
• Anatomic studies
• Glaucoma research

Background:

• Primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) are significant causes of vision loss.
• Understanding the anatomical factors contributing to PACG is crucial for early detection and management.

Purpose of the Study:

• To investigate the association of a novel biometric parameter, relative lens vault (LV), with primary angle-closure (PAC) and primary angle-closure glaucoma (PACG).

Main Methods:

• Evaluated 101 subjects with PAC (G) and 101 age- and gender-matched normal subjects.
• Measured anterior vault (AV) and LV using anterior-segment optical coherence tomography scans and customized software.
• Calculated relative LV by dividing LV by AV.

Main Results:

• Significant differences in LV and relative LV were found between PAC (G) eyes and normal eyes (P < 0.001).
• Relative LV values demonstrated superior discrimination between PAC (G) and normal eyes compared to absolute LV (AUC: 0.97 vs. 0.92).
• Anterior vault (AV) relative to axial length was similar between groups, suggesting normal anterior segment dimensions.

Conclusions:

• Relative dimensions of the anterior eye segment in PAC (G) eyes may fall within normal ranges.
• The relative LV, reflecting the lens vault in proportion to anterior vault, is more closely associated with PAC (G) than the absolute LV.
• Relative LV shows potential as a valuable diagnostic marker for PACG.