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Peptides come round: using SICLOPPS libraries for early stage drug discovery
Katherine R Lennard1, Ali Tavassoli
1Chemistry, University of Southampton, Southampton, SO17 1BJ (UK).
Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 22, 2014
Abstract:
Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.
Keywords:
SICLOPPScyclic peptidesdrug discoveryhigh throughput screeningmedicinal chemistryprotein-protein interactions
