Related Experiment Video

Updated: Apr 26, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.3K

Hypertrophic cardiomyopathy in adults: an overview

Cynthia Jacobs1

  • 1(ARNP Graduate Student), Venice Regional Medical Center, Gulf Coast Cardiovascular Consultants, University of Cincinnati, Sarasota, Florida.

Journal of the American Association of Nurse Practitioners
|July 22, 2014
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder often diagnosed late. Early recognition and treatment of HCM in adults can prevent sudden cardiac death, stroke, and heart failure, improving quality of life.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic disorder affecting the heart.
  • HCM often remains undiagnosed until midlife, presenting after symptoms of myocardial remodeling appear.
  • Adults with HCM face risks of sudden cardiac death (SCD), stroke, and heart failure.

Purpose of the Study:

  • To provide a comprehensive overview of clinical issues in adults with HCM.
  • To detail presenting symptoms, diagnostic methods, and physical examination findings for HCM.
  • To outline current treatment strategies and follow-up care for adult patients with HCM.

Main Methods:

  • A systematic literature search was conducted using Medline (PubMed) and CINAHL.
  • Key search terms included HCM, treatment, diagnosis, sudden cardiac death (SCD), and complications.
  • Twenty-one relevant articles and three reference books informed the content.

Main Results:

  • HCM is frequently diagnosed late, often after the onset of symptoms.
  • Untreated HCM can lead to serious adverse events, including SCD, stroke, and heart failure.
  • Early diagnosis and intervention are crucial for managing HCM.

Conclusions:

  • Early diagnosis of HCM in adults is critical for preventing SCD.
  • Prompt recognition and management of HCM can significantly improve patients' quality of life.
  • Timely intervention can slow disease progression, reducing the incidence of heart failure and stroke.
Abstract

Keywords:
Diastolic dysfunctiongeneticsheart failureprimary caresudden cardiac death

More Related Videos

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

6.6K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

9.9K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
801
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
746
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
813
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
786
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
936
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.7K