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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Vitamin D and chronic kidney disease
Chang Seong Kim1, Soo Wan Kim1
1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
The Korean Journal of Internal Medicine
|July 22, 2014
Summary
Vitamin D deficiency is common in chronic kidney disease (CKD) and may worsen kidney function. Supplementing active vitamin D may protect kidneys and reduce mortality in CKD patients.
Area of Science:
- Nephrology
- Endocrinology
- Nutritional Science
Background:
- Chronic kidney disease (CKD) is a major global health issue linked to high mortality.
- Vitamin D deficiency is prevalent in CKD patients, correlating inversely with kidney function.
- Emerging evidence suggests vitamin D deficiency exacerbates renal decline and mortality in CKD.
Purpose of the Study:
- To review vitamin D metabolism alterations in kidney disease.
- To explore potential renoprotective mechanisms of vitamin D.
- To discuss clinical outcomes of vitamin D treatment in CKD.
Main Methods:
- Review of experimental and clinical studies on vitamin D in CKD.
- Analysis of vitamin D's role in renal fibrosis, apoptosis, and inflammation.
- Examination of vitamin D's impact on proteinuria and mortality.
Main Results:
- Active vitamin D and analogues show renoprotective effects in animal models, reducing fibrosis, apoptosis, and inflammation.
- Treatment with active vitamin D analogs has been shown to decrease proteinuria and mortality in CKD patients.
- These benefits extend beyond bone and mineral metabolism, indicating pleiotropic effects.
Conclusions:
- Vitamin D plays a crucial role in CKD beyond mineral metabolism.
- Vitamin D treatment offers potential renoprotective benefits and may improve clinical outcomes in CKD.
- Further research is warranted to fully elucidate vitamin D's role and optimize treatment strategies in kidney disease.
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