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Previously unreported adverse reaction to encainide
R Goli-Bijanki1, C K Nair, N Nair
1Division of Cardiology and Allergy-Immunology, Creighton University School of Medicine, Omaha, NE.
Chest
|September 1, 1989
Summary
A patient experienced a new adverse reaction to encainide, including fever and myalgia, during atrial fibrillation treatment. Symptoms resolved after stopping encainide therapy, indicating a potential drug intolerance.
Area of Science:
- Cardiology
- Clinical Pharmacology
Background:
- Atrial fibrillation is a common arrhythmia requiring pharmacologic management.
- Encainide is an antiarrhythmic medication used for managing cardiac rhythm disorders.
Observation:
- A patient with recurrent atrial fibrillation presented with an unusual adverse reaction during encainide therapy.
- Symptoms included fever, chills, diaphoresis (sweating), and myalgia (muscle pain).
Findings:
- The patient experienced a similar adverse reaction upon re-administration of encainide, confirming a link.
- Discontinuation of encainide therapy led to the resolution of these symptoms.
Implications:
- This case highlights a previously unreported adverse effect of encainide.
- Clinicians should be aware of this potential reaction when prescribing encainide for atrial fibrillation.
- Further investigation into the mechanism of this encainide intolerance may be warranted.