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Updated: Apr 26, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Personalized oncology: genomic screening in phase 1
Ida Viller Tuxen1, Lars Jønson, Eric Santoni-Rugiu
1Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Genomic screening in cancer identifies specific mutations, enabling personalized treatments in early clinical trials. This approach aims to improve patient outcomes and accelerate the development of targeted therapies.
Area of Science:
- Oncology
- Genomics
- Translational Medicine
Background:
- Cancer development is increasingly understood to be driven by numerous genomic alterations.
- Advanced genomics technology allows for the characterization of these tumor-driving genomic alterations.
Purpose of the Study:
- To explore the utility of genomic screening in selecting patients for Phase 1 clinical trials.
- To investigate how genomic profiling can enhance targeted molecular therapy and accelerate drug development.
Main Methods:
- Utilizing advanced genomics technology for simultaneous screening of thousands of genes.
- Applying genomic mapping to identify patients for early-phase clinical trials with targeted therapies.
Main Results:
- Personalized molecular medicine is becoming a viable option due to comprehensive gene screening.
- Genomic selection for Phase 1 trials may improve patient outcomes and enrich trial populations.
Conclusions:
- Integrating genomic screening into Phase 1 trial selection can lead to better patient outcomes and faster drug development.
- Identifying mutation profiles that correlate with sensitivity to targeted therapies is a key advantage.
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