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Updated: Apr 26, 2026
10:28
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
6.1K
Therapeutic perspectives of epigenetically active nutrients
M Remely1, L Lovrecic2, A L de la Garza3
1Department of Nutritional Sciences, University Vienna, Vienna, Austria.
British Journal of Pharmacology
|July 23, 2014
Summary
Dietary compounds influence epigenetics, impacting gene expression and health. This field, nutriepigenetics, explores how nutrients like polyphenols affect diseases such as cancer and neurodegenerative disorders.
Area of Science:
- Nutritional science and epigenetics
- Molecular biology and disease mechanisms
Background:
- Nutrients play roles in disease prevention and health regulation.
- Emerging evidence links nutrients to epigenetic modifications, a field known as nutriepigenetics/nutriepigenomics.
- Polyphenols are key dietary compounds interacting with the genome and environment.
Purpose of the Study:
- To review the impact of dietary compounds on epigenetic mechanisms.
- To explore the regulation of gene expression by nutrients.
- To examine the role of nutriepigenetics in various diseases.
Main Methods:
- Literature review of nutriepigenetics and epigenetics research.
- Analysis of studies on dietary compounds and epigenetic modifications.
- Synthesis of findings related to gene expression and disease.
Main Results:
- Dietary compounds, particularly polyphenols, modulate epigenetic mechanisms.
- Epigenetic regulation by nutrients affects gene expression, including drug metabolism enzymes.
- Nutriepigenetics is relevant to cancer, metabolic syndrome, neurodegenerative disorders, and hormonal dysfunction.
Conclusions:
- Dietary compounds significantly influence epigenetic regulation of gene expression.
- Nutriepigenetics offers insights into disease prevention and management.
- Further research is needed to elucidate specific mechanisms in nutriepigenetics.
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