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Related Concept Videos

Centrioles and Centrosomes01:13

Centrioles and Centrosomes

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Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
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Centrosome Duplication02:25

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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Microtubules in Signaling01:22

Microtubules in Signaling

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Spindle Assembly02:50

Spindle Assembly

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Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
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Related Experiment Video

Updated: Apr 26, 2026

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

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Centrosomes as signalling centres.

Christian Arquint1, Anna-Maria Gabryjonczyk1, Erich A Nigg2

  • 1Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|July 23, 2014
PubMed
Summary

Centrosomes and spindle pole bodies may act as signaling hubs, integrating cellular pathways. Further research is needed to confirm their role beyond microtubule organization in various organisms and processes.

Keywords:
DNA damagecell cyclecentrosomemitosissignalling hubspindle pole body

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Last Updated: Apr 26, 2026

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

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Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Centrosomes and spindle pole bodies (SPBs) are known for microtubule organization and are linked to human diseases.
  • Their roles in biogenesis and duplication are well-studied.
  • Their potential function as signaling centers is less understood.

Purpose of the Study:

  • To explore the emerging concept of centrosomes and SPBs as signaling centers.
  • To review selected studies supporting this hypothesis across different organisms and processes.

Main Methods:

  • Literature review of selected studies.
  • Analysis of centrosome/SPB association with signaling components.
  • Examination of roles in cell cycle control, development, and DNA damage response.

Main Results:

  • Signaling components like kinases and phosphatases associate with centrosomes/SPBs.
  • Evidence suggests these organelles may integrate and coordinate signaling pathways.
  • The concept is supported by studies in yeast, invertebrates, and vertebrates.

Conclusions:

  • Centrosomes and SPBs show potential as signaling hubs.
  • This role requires further investigation and validation.
  • The field is nascent, with the signaling center hypothesis needing more scrutiny.