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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jul 17, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Liposarcoma: a soft tissue tumor with many presentations.

H J Mankin1, K P Mankin, D C Harmon

  • 1Departments of Orthopaedics, Pathology, Radiation Oncology, Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA, HMANKIN@PARTNERS.ORG.

Musculoskeletal Surgery
|July 23, 2014
PubMed
Summary

Liposarcoma, a rare soft tissue tumor from lipoblast cells, presents varied forms from benign to metastatic. Surgical resection is primary, with chemotherapy and radiation aiding malignant variants.

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Liposarcoma is a rare connective tissue tumor originating from lipoblast cells.
  • These tumors typically occur in soft body tissues but can rarely affect bones.
  • Liposarcoma exhibits diverse presentations, from well-differentiated benign types to aggressive dedifferentiated and pleomorphic forms capable of metastasis.

Purpose of the Study:

  • To provide an overview of liposarcoma, encompassing its pathology, clinical presentation, and treatment modalities.
  • To highlight the variability in liposarcoma subtypes and their metastatic potential.
  • To discuss the current therapeutic strategies for liposarcoma.

Main Methods:

  • Review of existing literature on liposarcoma.
  • Analysis of tumor characteristics and classification.
  • Summary of treatment outcomes for different liposarcoma variants.

Main Results:

  • Liposarcomas are classified into several subtypes with distinct clinical behaviors.
  • Surgical resection remains the primary treatment modality for most liposarcomas.
  • Chemotherapy and radiation show some efficacy in managing more aggressive, metastatic liposarcoma subtypes.

Conclusions:

  • Liposarcoma management requires a tailored approach based on tumor subtype and grade.
  • Multimodal therapy, including surgery, chemotherapy, and radiation, is crucial for advanced disease.
  • Further research into targeted therapies may improve outcomes for liposarcoma patients.