Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

7.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.9K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.5K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Longitudinal Comprehensive Biospecimen and Clinical Data Repository for Cancer Early Detection: The InAdvance Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Immunoglobulin light-chain amyloidosis in the setting of multiple myeloma diagnosed from oral biopsy.

Journal of the American Dental Association (1939)·2026
Same author

Lenalidomide for the Treatment of Chronic Oral Mucositis and Soft Tissue Necrosis After Radiation Therapy.

Practical radiation oncology·2026
Same author

Pemphigus foliaceus transforming to pemphigus vulgaris: a case report.

Frontiers in medicine·2026
Same author

Safety of topical imiquimod use in allogeneic hematopoietic stem cell transplant recipients: A multicenter retrospective analysis.

Journal of the American Academy of Dermatology·2025
Same author

Metastatic SMARCA4-Deficient Undifferentiated Carcinoma of the Oral Cavity: A Case Report and Review of Literature.

Head and neck pathology·2025
Same journal

Reply to the letter to the editor: Oral cancer YOLOv8 model in the context of power systems: background specificity blind spot and acquisition device dependency bottleneck.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same journal

Letter to the Editor on "YOLOv8 powered deep learning framework for detection and classification of oral potentially malignant disorders and oral cancer using intraoral images".

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same journal

Response to the letter regarding "artificial intelligence-assisted detection of soft tissue calcifications and ossifications in CBCT".

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same journal

General dentists' approach to dental management of patients taking anticoagulants: a national survey-based assessment: pre- and post-procedure practice.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same journal

Hospital dental management as an adjunct to systemic therapy in refractory oral candidiasis in severe combined immunodeficiency.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same journal

Application of zero-TE MRI for the disk calcification of the temporomandibular joint: two case reports.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

12.2K

Resorbable collagen membranes: histopathologic features.

Soulafa A Almazrooa1, Vikki Noonan2, Sook-Bin Woo3

  • 1Graduate student, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|July 23, 2014
PubMed
Summary
This summary is machine-generated.

Resorbable collagen membranes (RCMs) sometimes persist longer than expected in bone defects, potentially delaying healing. Histopathology revealed these non-resorbed RCMs as fibrillar material without a significant inflammatory response.

More Related Videos

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

13.0K
Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

9.6K

Related Experiment Videos

Last Updated: Apr 26, 2026

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

12.2K
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

13.0K
Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

9.6K

Area of Science:

  • Oral surgery
  • Periodontology
  • Endodontics
  • Biomaterials science

Background:

  • Resorbable collagen membranes (RCMs) are widely utilized in dental and oral surgical procedures.
  • Their intended function is to support tissue regeneration and be resorbed by the body over time.

Purpose of the Study:

  • To report cases where RCMs failed to resorb as anticipated.
  • To describe the histopathologic characteristics of these persistent RCMs.

Main Methods:

  • Analysis of biopsy specimens from bone showing unusual fibrillar foreign material.
  • Application of Hematoxylin-eosin and Masson trichrome staining.
  • Collection of clinical data through clinician interviews.

Main Results:

  • Six cases (3 male, 3 female) presented with non-resorbed RCMs.
  • Histopathology showed hyalinized, paucicellular, eosinophilic fibrils or meshwork without foreign body reaction.
  • RCMs persisted for 2-6 weeks in 3 cases and potentially impeded healing in 5 cases.

Conclusions:

  • RCMs can persist in wound sites longer than their expected resorption time.
  • These persistent membranes may not elicit a typical foreign body reaction.
  • Delayed resorption of RCMs might hinder wound healing processes.