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IMGT/HLA and the Immuno Polymorphism Database.

James Robinson1, Jason A Halliwell, Steven G E Marsh

  • 1Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK.

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|July 23, 2014
PubMed
Summary
This summary is machine-generated.

The Immuno Polymorphism Database (IPD) provides curated genetic sequences for immune system genes, including highly variable Human Leukocyte Antigen (HLA) genes. This resource aids researchers studying immune system diversity and function.

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Area of Science:

  • Immunogenetics
  • Bioinformatics
  • Molecular Biology

Background:

  • The IMGT/HLA Database has served the HLA research community for over 15 years.
  • The Human Leukocyte Antigen (HLA) complex on chromosome 6p21.3 comprises over 220 genes, many encoding highly polymorphic immune system proteins with thousands of allelic variants.
  • The Immuno Polymorphism Database (IPD) extends this by housing specialist databases for polymorphic immune genes.

Purpose of the Study:

  • To provide a comprehensive, searchable repository of curated genetic sequences for the immune system.
  • To expand the IPD with specialist databases covering killer-cell immunoglobulin-like receptors (KIR), major histocompatibility complex (MHC) sequences across species, platelet-specific alloantigens (HPA), and a tumor cell line database (ESTDAB).
  • To ensure public accessibility of this critical immunological data through a collaborative online platform.

Main Methods:

  • Curating and compiling allelic sequences for HLA genes.
  • Developing and integrating specialist databases: IPD-KIR, IPD-MHC, IPD-HPA, and IPD-ESTDAB.
  • Collaborating with nomenclature committees and specialist groups for data curation.
  • Providing public access via the http://www.ebi.ac.uk/ipd/ website.

Main Results:

  • The IMGT/HLA Database offers a searchable repository of highly curated HLA sequences.
  • The IPD now includes four distinct databases: IPD-KIR, IPD-MHC, IPD-HPA, and IPD-ESTDAB.
  • Public access to a wide range of polymorphic immune gene data is available through the IPD website.

Conclusions:

  • The IPD serves as a vital, expanding resource for researchers studying immune system polymorphism.
  • The collaborative curation model ensures high-quality, up-to-date data for the scientific community.
  • Publicly accessible databases like IPD are crucial for advancing research in immunogenetics and related fields.