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[Penicillin insensitive and resistant Streptococcus pneumoniae infection in children]
Abstract:
Five cases of penicillin insensitive or resistant pneumococcal infection in children were experienced during the period of 2 years since March, 1986. One isolate from middle ear showed the MIC of 4 micrograms/ml against penicillin-G. One isolate of insensitive pneumococcus was isolated from CSF specimen. Between 1976 and 1987, 59 isolates from 88 stocked pneumococcal clinical isolates were alive. These 59 strains were screened by oxacillin disc for insensitive and resistant pneumococcus. Five strains which were insensitive or resistant strains had inhibitory zone under 20 mm. The prevalence rate of insensitive or resistant pneumococcus since 1986 was 18%.
Insights
Penicillin-resistant pneumococcal infections in children are emerging, with 18% of isolates showing resistance since 1986. This highlights the need for monitoring antimicrobial resistance in pediatric infections.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Antimicrobial Resistance
Context:
- Pneumococcal infections pose a significant threat to children's health.
- Penicillin resistance in Streptococcus pneumoniae is a growing global concern.
- Limited data exists on the prevalence of penicillin-insensitive pneumococcal strains in pediatric populations.
Purpose:
- To investigate the occurrence and prevalence of penicillin-insensitive or resistant pneumococcal infections in children.
- To screen historical pneumococcal isolates for resistance markers.
- To determine the rate of antimicrobial resistance in pediatric pneumococcal isolates.
Summary:
- Over a two-year period starting March 1986, five cases of penicillin-insensitive or resistant pneumococcal infections were identified in children.
- One middle ear isolate exhibited a Minimum Inhibitory Concentration (MIC) of 4 µg/ml for penicillin-G.
- One cerebrospinal fluid (CSF) isolate demonstrated penicillin insensitivity.
- Screening of 59 viable pneumococcal strains from 1976-1987 using oxacillin discs identified five resistant strains (inhibitory zone < 20 mm).
- The prevalence of penicillin-insensitive or resistant pneumococcus was found to be 18% since 1986.
Impact:
- Findings indicate a significant prevalence (18%) of penicillin-insensitive or resistant pneumococcus in pediatric cases since 1986.
- Highlights the urgent need for enhanced surveillance of antimicrobial resistance in pediatric pneumococcal infections.
- Informs clinical decision-making regarding antibiotic selection for pneumococcal infections in children.