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Related Experiment Video

Updated: Apr 26, 2026

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

Research highlights: increasing paper possibilities.

Chueh-Yu Wu¹, Oladunni Adeyiga, Jonathan Lin

¹Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Box 951600, Los Angeles, California 90095, USA. dicarlo@ucla.edu.

|July 23, 2014

Summary

This summary is machine-generated.

New paper microfluidic strategies enhance diagnostic tests by concentrating low-analyte samples and enabling cell-based assays. These advancements improve sensitivity and expand applications beyond current lateral flow immunoassay capabilities.

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Last Updated: Apr 26, 2026

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

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Published on: April 1, 2016

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

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Published on: March 9, 2017

Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper

Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper

Published on: October 6, 2023

Area of Science:

Biomolecular assays
Microfluidics
Diagnostic tests

Background:

Paper-based microfluidics are widely used for rapid diagnostic tests like lateral flow immunoassays (LFAs).
Traditional LFAs require high analyte concentrations due to limited sample volume, restricting sensitivity.
Paper's small pores hinder the use of microfluidics for cell-based diagnostics.

Purpose of the Study:

To highlight new strategies extending paper microfluidic capabilities.
To address limitations in analyte concentration and cell handling in paper-based diagnostics.
To enable more sensitive and versatile paper-based diagnostic platforms.

Main Methods:

Development of methods for analyte enrichment in paper microfluidics.
Implementation of paper-based pumping for larger channels.
Integration of these techniques into novel assay formats.

Main Results:

Demonstrated strategies for concentrating analytes from low concentrations.
Enabled the use of paper microfluidics for larger particles and cell flows.
Showcased enhanced capabilities for paper-based biomolecular assays.

Conclusions:

New strategies significantly extend the capabilities of paper microfluidics.
These advancements can lead to more sensitive diagnostics for previously unachievable disease states.
Paper-based assays can maintain advantages like "un-instrumented" operation with improved performance.