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Updated: Apr 26, 2026

Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
Published on: January 24, 2020
Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
Dario Sangiolo1, Giulia Mesiano2, Loretta Gammaitoni3
1Department of Oncology; University of Torino; Torino, Italy ; Laboratory of Medical Oncology; Experimental Cell Therapy Unit; Candiolo Cancer Institute; Candiolo, Turin, Italy.
Abstract:
Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.
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