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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Sleep apnea awakens cancer: A unifying immunological hypothesis
David Gozal1, Isaac Almendros1, Fahed Hakim1
1Department of Pediatrics; Comer Children's Hospital; Pritzker School of Medicine; University of Chicago; Chicago, IL USA.
Abstract:
The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OSA, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.
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