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Updated: Apr 26, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1/PD-L1 pathway
Toshihiro Nagato1, Esteban Celis2
1Department of Otolaryngology-Head and Neck Surgery; Asahikawa Medical University; Asahikawa, Japan ; Immunology Program; Moffitt Cancer Center; Tampa, FL USA.
Abstract:
A non-antigen specific immunotherapy consisting of repeated co-administration of poly-IC and blocking antibodies targeting the programmed cell death-1 (PD-1) pathway dramatically inhibits tumor development in several mouse models of cancer. Tumor-reactive CD8+ T cells mediate the antitumor effects mediated by PD-1 blockade. This therapeutic avenue can be readily translated to cancer patient treatment regimens.
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