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Orbital schwannoma: a clinicopathologic study.
Neelam Pushker1, Saurbhi Khurana, Seema Kashyap
1Oculoplasty and Paediatric Ophthalmology Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
International Ophthalmology
|July 24, 2014
Summary
Orbital schwannomas are rare tumors with varied imaging features. Histopathology, including Antoni A and B areas, is key for definitive diagnosis, correlating with imaging findings like hypodense or cystic areas.
Area of Science:
- Ophthalmology
- Pathology
- Radiology
Background:
- Orbital schwannomas are rare tumors affecting the orbit.
- Understanding their characteristics is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the clinical, radiological, and histopathological features of orbital schwannomas.
- To correlate imaging findings with histopathological characteristics.
Main Methods:
- Retrospective analysis of 49 orbital schwannoma cases operated between 1993 and 2011.
- Review of clinical data, imaging (CT, USG), and histopathological findings.
- Correlation of imaging features with histopathological subtypes (Antoni A and B areas).
Main Results:
- Orbital schwannomas occurred in a wide age range (8-65 years) with female preponderance.
- Median symptom duration was 3 years; imaging showed variable density and enhancement.
- Histopathology revealed mixed Antoni A and B areas; hypodense/cystic imaging correlated with Antoni B areas.
Conclusions:
- Orbital schwannoma is a rare tumor with diverse presentations.
- Imaging features are variable, necessitating histopathological and immunohistochemical confirmation for diagnosis.
