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Updated: Apr 26, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
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Flow-regulated lymphatic vasculature development and signaling
1Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA.
Vascular Cell
|July 24, 2014
Summary
Fluid flow significantly influences lymphatic vessel development and maintenance. This review highlights how fluid dynamics control lymphatic vascular growth, regeneration, and fate.
Area of Science:
- Physiology
- Vascular Biology
- Biophysics
Background:
- Blood flow's role in vascular signaling is established.
- Emerging evidence shows fluid shear stress impacts lymphatic vessels.
Purpose of the Study:
- To review advances in understanding flow-mediated signaling in lymphatic circulation.
- To focus on fluid dynamics' role in lymphatic vasculature formation.
Main Methods:
- Literature review of recent studies on lymphatic vascular biology.
- Analysis of research on mechanotransduction in lymphatic endothelial cells.
Main Results:
- Flow-mediated signaling regulates lymphatic vascular growth and remodeling.
- Fluid dynamics are critical for lymphatic vessel maintenance and regeneration.
- Mechanotransduction pathways are key to lymphatic vascular fate.
Conclusions:
- Fluid dynamics are a crucial regulator of lymphatic vasculature formation and function.
- Understanding these mechanisms can inform therapeutic strategies for lymphatic disorders.
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