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Neuroprotection of microRNA in neurological disorders (Review)
Chunmei Wang1, Bingyuan Ji2, Baohua Cheng1
1Neurobiology Institute, Jining Medical University, Jining 272067, P.R. China.
Abstract:
MicroRNAs (miRNAs) are small, endogenous, non-coding RNA molecules that function as post-transcriptional regulators of gene expression by imperfect base-pairing with the 3'-untranslated regions of their target mRNAs. Altered expression of numerous miRNAs has been shown to be extensively involved in the pathogenesis of various diseases and cancers. Additionally, the specific expression of miRNAs in the nervous system has indicated that miRNAs are critical for the occurrence and development of neurological diseases. Increasing evidence has shown that specific miRNAs target the expression of particular proteins that are significant in the disease pathogenesis. Therefore, miRNA-mediated regulation may be important in the occurrence and development of neurological diseases and may function as a novel biomarker and tool for clinical therapy. In the present study, the significance of miRNAs is reviewed in a number of neurological disorders and the possibility of their use in therapeutic interventions is evaluated.
Insights
MicroRNAs (miRNAs) are key regulators in neurological disease development. This review explores their role in neurological disorders and potential as therapeutic biomarkers.
Area of Science:
- Molecular Biology
- Neuroscience
- Genetics
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
- Aberrant miRNA expression is implicated in various diseases, including cancers and neurological disorders.
- Specific miRNA expression patterns in the nervous system highlight their critical role in neurological disease pathogenesis.
Purpose of the Study:
- To review the significance of miRNAs in neurological disorders.
- To evaluate the potential of miRNAs as biomarkers and therapeutic targets in neurology.
Main Methods:
- Literature review of studies on miRNA involvement in neurological diseases.
- Analysis of miRNA-mediated gene regulation in disease pathogenesis.
- Evaluation of current and future therapeutic applications of miRNAs.
Main Results:
- Specific miRNAs target key proteins involved in neurological disease development.
- miRNA dysregulation is a significant factor in the occurrence and progression of neurological conditions.
- miRNAs show promise as novel biomarkers for diagnosis and prognosis.
Conclusions:
- miRNA-mediated gene regulation is crucial in neurological disease.
- miRNAs represent a potential avenue for novel clinical therapies and diagnostic tools in neurology.
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