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Anticancer Tc9 cells: Long-lived tumor-killing T cells for adoptive therapy
Yong Lu1, Qiang Wang1, Qing Yi1
1Department of Cancer Biology; Lerner Research Institute; Cleveland Clinic; Cleveland, OH USA.
Oncoimmunology
|July 24, 2014
Abstract:
IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8+ T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are highly significant and crucial to achieve advances in T cell-based adoptive therapies.
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