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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

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Myeloid-derived suppressor cells link inflammation to cancer

Dingzhi Wang1, Raymond N DuBois2

  • 1Laboratory for Inflammation and Cancer; the Biodesign Institute at Arizona State University; Tempe, AZ USA.

Oncoimmunology
|July 24, 2014
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) drive chronic colonic inflammation and cancer development. Targeting MDSCs offers a new strategy against inflammation- and tumor-induced immunosuppression.

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Chronic colonic inflammation is a risk factor for colitis-associated cancer.
  • The role of myeloid-derived suppressor cells (MDSCs) in this process is not fully understood.

Purpose of the Study:

  • To investigate the role of MDSCs in chronic colonic inflammation and colitis-associated carcinogenesis.
  • To explore MDSCs as therapeutic targets for cancer treatment.

Main Methods:

  • Utilized models of chronic colonic inflammation and cancer.
  • Assessed the impact of MDSCs on disease progression and immune suppression.

Main Results:

  • MDSCs were found to promote chronic colonic inflammation.
  • MDSCs were identified as key drivers of colitis-associated carcinogenesis.
  • MDSCs contribute to inflammation- and tumor-induced immunosuppression.

Conclusions:

  • MDSCs play a critical role in linking chronic inflammation to cancer development in the colon.
  • Targeting MDSCs presents a promising therapeutic strategy to overcome immunosuppression in colitis-associated cancer.
Keywords:
CXCR2colitis-associated tumorigenesiscolorectal cancerinflammationmyeloid-derived suppressor cells

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