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Detection of Copy Number Alterations Using Single Cell Sequencing
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A schematic workflow for collecting information about the interaction between copy number variants and microRNAs

Harsh Dweep1, Norbert Gretz, Kyriakos Felekkis

  • 1Medical Faculty Mannheim, Medical Research Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, D-68167, Germany, harsh.dweep@medma.uni-heidelberg.de.

Methods in Molecular Biology (Clifton, N.J.)
|July 25, 2014
PubMed

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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