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Age-related decrease of the phosphorus content in the ligamentum capitis femoris of monkeys
Yoshiyuki Tohno1, Setsuko Tohno, Takao Oishi
1Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand, ytohno@med.cmu.ac.th.
Biological Trace Element Research
|July 25, 2014
Summary
This study analyzed elemental changes in monkey ligaments with aging. Phosphorus levels significantly decreased, suggesting reduced active cell density in juvenile connective tissues.
Area of Science:
- Biochemistry
- Connective Tissue Research
- Aging Studies
Background:
- The ligamentum capitis femoris (LCF) composition changes with age.
- Understanding these changes is crucial for aging research.
- Previous studies have not fully elucidated age-related elemental shifts in LCF.
Purpose of the Study:
- To investigate age-related elemental compositional changes in the monkey LCF.
- To correlate elemental changes with potential indicators of cell density and protein content.
- To identify significant elemental relationships within the LCF across different ages.
Main Methods:
- Direct chemical analysis of LCF samples from rhesus and Japanese monkeys (newborn to 31 years).
- Sample incineration using nitric and perchloric acids.
- Inductively coupled plasma-atomic emission spectrometry for element quantification.
Main Results:
- A significant decrease in phosphorus (P) content was observed in LCF with aging.
- Calcium (Ca), sulfur (S), magnesium (Mg), zinc (Zn), iron (Fe), and sodium (Na) levels showed no significant age-related changes.
- The P/S ratio, indicative of active cell density to protein amount, significantly decreased during childhood.
Conclusions:
- Phosphorus levels in LCF may serve as an indicator of active cell density.
- A significant decline in active cell density occurs in the LCF during childhood.
- Significant correlations exist between Ca, P, S, and Mg content in the LCF.
