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Updated: Apr 26, 2026
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Prioritized current unmet needs for antibacterial therapies.
1Division of Infectious Diseases, Keck School of Medicine at the University of Southern California and LAC+USC Medical Center, Los Angeles, California, USA.
Clinical Pharmacology and Therapeutics
|July 25, 2014
Summary
New antibacterial treatments are crucial due to rising antibiotic resistance and few drug approvals. This study prioritizes areas of greatest unmet need for developing new antibacterial drugs to combat serious infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Drug Development
Background:
- Declining new antibacterial approvals pose a significant public health threat.
- Increasing antibiotic resistance necessitates novel therapeutic strategies.
- Existing treatments face challenges due to evolving resistance patterns.
Purpose of the Study:
- To identify and prioritize critical areas for new antibacterial drug development.
- To address the most serious treatment challenges in bacterial infections.
- To guide future research and development efforts in antibacterials.
Main Methods:
- Analysis of current antibiotic resistance trends.
- Evaluation of treatment strategies and their effectiveness.
- Prioritization of unmet needs based on clinical impact.
Main Results:
- Identification of specific bacterial pathogens and infection types with high unmet needs.
- Assessment of the severity of treatment challenges in various clinical settings.
- Ranking of development priorities based on resistance and clinical outcomes.
Conclusions:
- Urgent need for novel antibacterials targeting resistant pathogens.
- Strategic development is required to address evolving resistance.
- Prioritization will optimize resource allocation for new antibacterial therapies.
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