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Role of cancer stem cell-associated inflammation in creating pro-inflammatory tumorigenic microenvironments
1Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan.
Abstract:
We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammation-driven carcinogenesis. These findings clarify a molecular pathway linking cancer "stemness" and pro-tumor inflammation in an immunosuppressive niche.
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