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Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides
M Marastoni1, S Salvadori, G Balboni
1Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Arzneimittel-Forschung
|June 1, 1989
Abstract:
Dermorphin- growth hormone releasing factor (GRF) hybrid peptides (Y-Tyr-D-Ala-Xaa-Gly-Tyr-Pro-Ser-NH2) were synthesized and tested for opioid activity and their ability to stimulate growth hormone (GH) secretion. The substitution of Phe3 for Asp and Glu in dermorphin or its N-terminal acetylation produced peptides with no affinity for opioid receptors but significant, even if low, GRF-like activity.