Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

12.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
12.7K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

10.8K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.8K
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

413
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
413
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

16
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
16

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparisons of Validity of the New and Prior MCAT Exams in Predicting Performances on Steps 1, 2, and 3 of the United States Medical Licensing Examinations.

Teaching and learning in medicine·2025
Same author

Inspiring Undergraduate Student Training in Alzheimer's Research (USTAR): Training the Next Generation of Aging Scientists.

Journal of the American Geriatrics Society·2025
Same author

Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury.

Arteriosclerosis, thrombosis, and vascular biology·2023
Same author

Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.

Journal of molecular and cellular cardiology·2023
Same author

Structural competency in emergency medical education: A scoping review and operational framework.

AEM education and training·2022
Same author

Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.

Circulation research·2022
Same journal

Why Dispelling Myths and Misconceptions in Emergency Medicine Matters.

Emergency medicine clinics of North America·2026
Same journal

Myths and Misconceptions in Emergency Medicine.

Emergency medicine clinics of North America·2026
Same journal

Acute Otitis Media-Watch and Wait Is Not a Myth.

Emergency medicine clinics of North America·2026
Same journal

Hot or Not? Myths and Misconceptions About Antipyretics for Pediatric Fever.

Emergency medicine clinics of North America·2026
Same journal

Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.

Emergency medicine clinics of North America·2026
Same journal

Myth: Pretreatment Prevents Intravenous Contrast Reactions in the Emergency Department.

Emergency medicine clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

165

Acquired bleeding disorders.

Alisheba Hurwitz1, Richard Massone1, Bernard L Lopez1

  • 1Department of Emergency Medicine, Thomas Jefferson University Hospital, 1020 Sansom Street, Thompson Building, Suite 239, Philadelphia, PA 19107, USA.

Emergency Medicine Clinics of North America
|July 26, 2014
PubMed
Summary
This summary is machine-generated.

Emergency clinicians frequently encounter bleeding patients with hemostasis disorders. This review outlines systematic assessment and management strategies, focusing on iatrogenic and acquired causes relevant to emergency medicine practice.

Keywords:
AnticoagulantBleedingCoagulopathyEmergencyHemorrhageHemostasisThrombocytopeniaTransfusion

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.4K

Related Experiment Videos

Last Updated: Apr 26, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

165
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.4K

Area of Science:

  • Emergency Medicine
  • Hematology

Background:

  • Bleeding patients are common in emergency medicine.
  • Disorders of hemostasis present a significant challenge.
  • Systematic assessment and management are crucial.

Purpose of the Study:

  • To provide emergency clinicians with a systematic approach to hemostasis disorders.
  • To highlight iatrogenic and acquired causes of abnormal hemostasis.
  • To aid in the assessment and management of bleeding patients.

Main Methods:

  • Review of existing literature on hemostasis disorders in emergency medicine.
  • Focus on iatrogenic causes.
  • Discussion of acquired causes including renal disease, immune thrombocytopenia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, acquired coagulation factor inhibitors, acute traumatic coagulopathy, liver disease, and disseminated intravascular coagulopathy.

Main Results:

  • Iatrogenic causes of abnormal hemostasis are of particular importance to emergency clinicians.
  • Various acquired conditions can lead to hemostasis disorders.
  • A systematic approach allows for effective management.

Conclusions:

  • Emergency medicine practitioners can systematically assess and manage hemostasis disorders.
  • Understanding iatrogenic and acquired causes is key to effective patient care.
  • Timely and appropriate management improves outcomes for bleeding patients.