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Complement System

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...

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Related Experiment Video

Updated: Apr 26, 2026

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model

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Published on: February 11, 2021

Lessons learned from mice deficient in lectin complement pathway molecules.

Ninette Genster¹, Minoru Takahashi², Hideharu Sekine²

¹Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631 Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Molecular Immunology

|July 26, 2014

Summary

This summary is machine-generated.

Mice lacking key lectin pathway complement molecules reveal its crucial roles in immunity, coagulation, and development. These knockout models advance understanding of complement deficiencies in human health and disease.

Keywords:

Complement Ficolin Knockout mice Lectin pathway MASP Mannose-binding lectin

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Area of Science:

Immunology
Complement System Biology

Background:

The lectin pathway initiates complement activation via pattern-recognition molecules like mannose-binding lectin (MBL).
MASPs activate downstream complement, leading to pathogen elimination.
Understanding the lectin pathway is vital for human health and disease research.

Purpose of the Study:

To review the generation and findings from mice deficient in lectin pathway molecules.
To highlight the insights gained into the lectin pathway's functions in vivo.

Main Methods:

Generation of knockout mice lacking key lectin pathway components.
In vivo investigations to study the effects of these deficiencies.

Main Results:

Lectin pathway knockout mice serve as valuable models for human deficiency states.
Studies revealed diverse roles in complement activation, pathogen infection, coagulation, tissue injury, and development.
Unexpected findings have expanded knowledge of lectin pathway molecule functions.

Conclusions:

Mice deficient in lectin pathway molecules are essential tools for biological research.
These models provide critical insights into the complex roles of the lectin pathway in various physiological and pathological processes.