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Updated: Apr 26, 2026
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative
Felipe A Calvo1, Morena Sallabanda2, Claudio V Sole1
1Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain ; School of Medicine Complutense University, Madrid, Spain ; Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Intraoperative electron-radiation therapy (IOeRT) is a valuable multidisciplinary approach for cancer management, demonstrated by over 1000 patients treated over 17 years. This initiative supports both clinical care and innovative cancer research.
Area of Science:
- Oncology
- Radiation Oncology
- Surgical Oncology
Background:
- Intraoperative radiotherapy (IORT) involves delivering a high radiation dose during surgery.
- Intraoperative electron-radiation therapy (IOeRT) is a key component in multidisciplinary cancer treatment.
Purpose of the Study:
- To analyze clinical and research innovations over 17 years using IOeRT in cancer management.
- To evaluate the role of IOeRT within a multidisciplinary oncology approach.
Main Methods:
- A hospital-based database registered 1036 IOeRT procedures from 1995 to 2012.
- Research and development in imaging and treatment planning were active from 2006 onwards.
Main Results:
- 1004 patients, with a median age of 61, underwent IOeRT.
- The majority of cases (77%) were primary cancers, with gastrointestinal cancers (62%) being most common.
- Doses ranged from 7.5 to 15 Gy, with 12.5 Gy being the most frequent (49%).
Conclusions:
- An IORT program in an academic hospital fosters intensive clinical activity and patient care.
- IOeRT initiatives generate significant patient-oriented research, development, and innovation.
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