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Injectable cross-linked collagen with improved flow properties.

D G Wallace1, W Rhee, H Reihanian

  • 1Connective Tissue Research Laboratories, Collagen Corporation, Palo Alto, California 94303.

Journal of Biomedical Materials Research
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Glutaraldehyde cross-linked collagen is more resistant to flow than non-cross-linked collagen. Blending with hyaluronic acid improves injectability and reduces aggregate size for better tissue integration.

Area of Science:

  • Biomaterials Science
  • Rheology
  • Dermal Fillers

Background:

  • Fibrillar collagen is widely used in biomedical applications.
  • Cross-linking collagen affects its physical and mechanical properties.
  • Understanding rheological behavior is crucial for injectable biomaterials.

Purpose of the Study:

  • To compare the rheological properties of cross-linked and non-cross-linked fibrillar collagen.
  • To evaluate the impact of hyaluronic acid blending on cross-linked collagen's injectability and rheology.
  • To correlate in vitro rheological findings with in vivo implantation outcomes.

Main Methods:

  • Rheometry (Couette flow, shear creep, uniaxial creep, porous bed flow)
  • Particle size analysis

Related Experiment Videos

  • Microscopic techniques
  • In vivo dermal implantation studies (pig and human)

    • Main Results:

    • Cross-linked collagen exhibited significantly higher resistance to deformation and flow compared to non-cross-linked collagen.
    • In vivo studies showed cross-linked collagen was harder to inject and less uniform, forming lumps.
    • Blending with hyaluronic acid (5 mg/mL) improved injectability and reduced aggregate size, lowering deformation forces.

    Conclusions:

    • Glutaraldehyde cross-linking enhances collagen's resistance to deformation but impairs injectability.
    • Hyaluronic acid effectively mitigates the negative rheological effects of cross-linking, improving the performance of collagen-based dermal formulations.
    • Rheological properties directly influence the clinical performance of injectable collagen biomaterials.