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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Cancer stem cell detection and isolation.

Meysam Moghbeli1, Faezeh Moghbeli, Mohammad Mahdi Forghanifard

  • 1Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Medical Oncology (Northwood, London, England)
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PubMed
Summary

Identifying cancer stem cells (CSCs) is crucial for targeted therapies due to their role in metastasis and treatment resistance. This review details practical protocols for isolating these critical cells from various solid tumors.

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Metastatic tumors, not primary ones, cause most cancer deaths.
  • Cancer stem cells (CSCs) are implicated in tumor metastasis, dormancy, and resistance to chemotherapy.
  • Differentiating CSCs from normal stem cells is vital for effective cancer treatment.

Purpose of the Study:

  • To review practical and specific protocols for isolating cancer stem cells (CSCs) from solid tumors.
  • To highlight the importance of CSC identification for developing targeted cancer therapies.

Main Methods:

  • Review of established and novel protocols for CSC isolation.
  • Focus on methods applicable to solid tumors from various organs (colon, esophagus, liver, breast, brain, cervix).

Main Results:

  • The review consolidates key methodologies for CSC isolation.
  • It emphasizes the need for specific markers and techniques to distinguish CSCs.

Conclusions:

  • Accurate isolation of CSCs is imperative for advancing targeted cancer therapies.
  • Effective CSC identification can combat tumor relapse and chemotherapeutic resistance.