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Serum nesfatin-1 levels in overt and subclinical hyperthyroidism
1Department of Endocrinology and Metabolic Diseases Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey - askn79@yahoo.com.
Minerva Endocrinologica
|July 29, 2014
Summary
Serum nesfatin-1 levels remain unchanged in hyperthyroidism, suggesting this anorexigenic peptide is not involved in regulating appetite or body weight in this condition.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Research
Background:
- Nesfatin-1, an anorexigenic peptide derived from nucleobindin-2, inhibits food intake.
- Hyperthyroidism is associated with increased appetite and carbohydrate cravings, but the underlying mechanisms are unclear.
Purpose of the Study:
- To investigate the role of nesfatin-1 in appetite and body weight regulation in hyperthyroidism.
- To determine if serum nesfatin-1 levels differ in patients with subclinical and overt hyperthyroidism compared to controls.
Main Methods:
- Serum nesfatin-1 levels were measured using ELISA in 70 hyperthyroid patients (35 subclinical, 35 overt) and 35 controls.
- Statistical analysis adjusted for age and body mass index.
Main Results:
- No significant difference in serum nesfatin-1 levels was observed between the three groups (P=0.293).
- Adjusted analyses confirmed no significant differences between controls and hyperthyroid groups (P=0.567 and P=0.519).
Conclusions:
- Serum nesfatin-1 levels do not significantly change in overt and subclinical hyperthyroidism.
- Nesfatin-1 may not play a significant role in the altered appetite observed in hyperthyroidism.
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