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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
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MicroRNA Expression in Coronary Artery Disease
John F O'Sullivan, Antoinette Neylon, Catherine McGorrian
1Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
Microrna (Shariqah, United Arab Emirates)
|July 30, 2014
Summary
MicroRNAs (miRNAs) are key regulators in atherosclerosis pathogenesis. This review explores their role as potential biomarkers and therapeutic targets for coronary artery disease, highlighting current evidence and challenges.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- RNA Biology
Background:
- Atherosclerosis pathogenesis involves inflammation, cellular changes, and neointima formation.
- Key cells include endothelial cells, smooth muscle cells, and monocytes.
- MicroRNAs (miRNAs) are small, non-coding RNAs influencing these processes.
Purpose of the Study:
- To review the role of miRNAs in coronary artery disease (CAD) pathogenesis.
- To discuss the potential of miRNAs as biomarkers for CAD.
- To explore miRNAs as therapeutic targets for atherosclerosis.
Main Methods:
- Review of experimental and clinical evidence.
- Analysis of miRNA involvement in atherosclerosis.
- Assessment of biomarker and therapeutic potential.
Main Results:
- miRNAs significantly impact atherosclerosis development and progression.
- miRNA profiles show promise as biomarkers for CAD.
- miRNAs represent potential therapeutic targets for atherosclerosis.
Conclusions:
- miRNAs are crucial in CAD pathogenesis, offering diagnostic and therapeutic opportunities.
- Further research is needed to overcome data limitations and clinical challenges.
- miRNAs hold significant potential for advancing CAD management.
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