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Related Experiment Videos

Blood loses it when nerves go bad.

Ninib Baryawno1, David T Scadden1

  • 11] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [3] Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Cell Research
|July 30, 2014
PubMed
Summary

Sympathetic nerve activity reduction limits bone marrow mesenchymal cells, promoting hematopoietic stem cell expansion and myeloproliferative neoplasms. This study reveals a novel link between nerve function and blood stem cell disorders.

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Area of Science:

  • Hematology
  • Neuroscience
  • Stem Cell Biology

Background:

  • Myeloproliferative neoplasms (MPNs) are stem cell disorders characterized by abnormal blood cell production.
  • The bone marrow microenvironment plays a critical role in regulating hematopoietic stem cell (HSC) function.
  • The influence of the nervous system on HSCs and MPN pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the role of sympathetic nerve fibers in the regulation of bone marrow mesenchymal cells.
  • To determine the impact of modulating sympathetic activity on hematopoietic stem cell populations.
  • To explore the potential contribution of these mechanisms to the progression of myeloproliferative neoplasms.

Main Methods:

  • The study utilized mouse models to investigate the effects of sympathetic nerve abrogation.

Related Experiment Videos

  • Bone marrow mesenchymal cells, specifically Nestin-expressing cells, were quantified.
  • Hematopoietic stem cell populations and MPN progression were assessed following nerve modulation.

    • Main Results:

    • Abrogation of sympathetic nerve fibers led to a reduction in bone marrow Nestin mesenchymal cells.
    • This reduction in mesenchymal cells resulted in an expansion of hematopoietic stem cells.
    • The observed changes were associated with the progression of myeloproliferative neoplasms.

    Conclusions:

    • Sympathetic nerve activity influences the bone marrow microenvironment by regulating Nestin mesenchymal cells.
    • Modulation of sympathetic innervation can impact hematopoietic stem cell behavior.
    • Targeting the neuro-osseous interaction presents a potential therapeutic avenue for myeloproliferative neoplasms.