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Pin1: a molecular orchestrator in the heart
Nirmala Hariharan1, Mark A Sussman1
1Department of Biology, San Diego State University Heart Institute, San Diego State University, North Life Sciences, San Diego, CA.
Abstract:
Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.
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