Neutrophilic Fixed Drug Eruption
Leah Waldman1, Swathi B Reddy, Andrea Kassim
1*Rush Medical College, Rush University, Chicago, IL; †Department of Surgery, Yale University Medical Center, New Haven, CT; ‡Department of Dermatology, Rush University Medical Center, Chicago, IL; and §Department of Pathology, Rush University Medical Center, Chicago, IL.
The American Journal of Dermatopathology
|July 30, 2014
Summary
Fixed drug eruption (FDE) typically presents with localized skin lesions and lymphocytic inflammation. This case report details an unusual FDE presentation in a pregnant woman with widespread lesions and neutrophilic infiltrate.
Area of Science:
- Dermatology
- Pathology
- Pharmacology
Background:
- Fixed drug eruption (FDE) is a specific type of adverse cutaneous drug reaction.
- It is characterized by recurrence at the same skin site upon re-exposure to the causative drug.
- Classical histopathology shows interface dermatitis with a lymphocytic infiltrate.
Observation:
- A 27-year-old pregnant woman presented with atypical FDE.
- Her lesions were widespread, deviating from the typical localized presentation.
- Histopathologic examination revealed a predominantly neutrophilic infiltrate.
Findings:
- This case highlights an unusual presentation of FDE.
- The observed neutrophilic infiltrate contrasts with the classical lymphocytic pattern.
- Pregnancy may be a factor in the atypical presentation of FDE.
Implications:
- This case expands the understanding of FDE clinical and histopathological variations.
- It suggests considering FDE in pregnant women with unusual cutaneous drug reactions.
- Further research may elucidate the role of pregnancy in FDE pathogenesis.
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