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Updated: Apr 26, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
The benefit of atrial septal defect closure in elderly patients
Monika Komar1, Tadeusz Przewlocki1, Maria Olszowska1
1Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University, Krakow, Poland.
Insights
Transcatheter closure of atrial septal defects (ASDs) in patients over 60 significantly improves exercise capacity and quality of life. This percutaneous treatment is safe and effective, offering long-term clinical and hemodynamic benefits in the elderly.
Area of Science:
- Cardiology
- Interventional Cardiology
- Geriatric Cardiology
Background:
- Atrial septal defects (ASDs) in elderly patients present a controversial treatment scenario.
- Transcatheter closure is an alternative to surgical repair for ASDs.
Purpose of the Study:
- To evaluate the outcomes of transcatheter closure for secundum ASDs in patients aged 60 years and older.
- To assess improvements in exercise capacity, quality of life, and hemodynamic parameters post-procedure.
Main Methods:
- Analysis of 75 patients (mean age 65.3 years) with isolated secundum ASDs undergoing transcatheter closure.
- Pre- and post-procedure assessments included exercise tests, echocardiography, and the SF-36 Health Survey at 12 months.
Main Results:
- Successful device implantation in all patients with no major complications.
- Significant improvements in exercise time (P<0.001) and oxygen consumption (P<0.001) at 6 and 12 months.
- Marked improvement in 7 of 8 SF-36 quality of life parameters and significant reduction in right heart dimensions.
Conclusions:
- Transcatheter closure of ASDs in elderly patients leads to significant clinical and hemodynamic improvements.
- These benefits are maintained during long-term follow-up, supporting the procedure's efficacy in older individuals.
Objective:
Closure of an atrial septal defect in elderly patients is controversial. The aim of the study was to evaluate the outcomes of transcatheter closure of secundum atrial septal defects (ASDs) in elderly patients.
Patients And Methods:
From a total of 488 patients with ASDs who underwent transcatheter closure, 75 patients aged over 60 years (45 female, 30 male) with a mean age of 65.3±15.7 (60-75) years were analyzed. All patients had an isolated secundum ASD with a mean pulmonary blood flow:systemic blood flow of 2.84±1.9 (1.5-3.9). Symptom-limited treadmill exercise tests with respiratory gas-exchange analysis and transthoracic color Doppler echocardiographic study, as well as quality of life measured using the Short Form (36) Health Survey (SF-36) were repeated in all patients before the procedure and after 12 months of follow-up.
Results:
The atrial septal device was successfully implanted in all patients (procedure time 37.7±4.5 [13-59] minutes, fluoroscopy time 11.2±9.9 [6-40] minutes). There were no major complications. The defect echo diameter was 17.7±15.8 (12-30) mm. The mean balloon-stretched diameter of ASDs was 22.4±7.9 (14-34) mm. The diameter of the implanted devices ranged from 16 to 34 mm. Significant improvement of exercise capacity was noted at 6 and 12 months after the procedure. Exercise time within 6 months of ASD closure was longer (P<0.001) compared to baseline values, and also oxygen consumption increased (P<0.001). Seven quality-of-life parameters (except mental health) improved at 12-month follow-up compared to baseline data. The mean SF-36 scale increased significantly in 66 (88%) patients, with a mean of 46.2±19.1 (5-69). As early as 1 month after the procedure, a significant decrease of the right ventricular dimension and the right atrium dimension was observed (P<0.001). The right ventricular dimension decreased in 67 patients (89.3%).
Conclusion:
Closure of ASDs in elderly patients caused significant clinical and hemodynamic improvement after percutaneous treatment, which was maintained during long-term follow-up, justifying this procedure in old age.
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