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Flammer syndrome.

Katarzyna Konieczka1, Robert Ritch2, Carlo Enrico Traverso3

  • 1Department of Ophthalmology, University of Basel, Mittlere Strasse 91, 4031 Basel, Switzerland.

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|July 31, 2014
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Summary
This summary is machine-generated.

Flammer syndrome is a condition of vascular dysregulation affecting various organs, particularly the eye. While offering some protection against atherosclerosis, it is linked to diseases like normal tension glaucoma.

Keywords:
Cold extremitiesFlammer syndromeNormal tension glaucomaOptic disc hemorrhagesPredictive preventive personalized medicinePrimary vascular dysregulationRetinal vein occlusionSystemic hypotensionTinnitusVasospasm

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Genetics

Background:

  • Flammer syndrome is a newly defined phenotype characterized by primary vascular dysregulation.
  • It presents with a cluster of symptoms and signs affecting healthy individuals and those with diseases.
  • Vascular reactivity to stimuli like cold and stress is altered in affected individuals.

Purpose of the Study:

  • To describe the Flammer syndrome phenotype.
  • To highlight its association with specific health conditions, particularly normal tension glaucoma.
  • To identify demographic and clinical characteristics associated with the syndrome.

Main Methods:

  • Phenotypic characterization of individuals with Flammer syndrome.
  • Analysis of vascular responses to stimuli.
  • Assessment of ocular blood flow and associated risk factors for glaucoma.

Main Results:

  • Flammer syndrome involves altered blood vessel reactivity, impacting various organs, especially the eye.
  • It is more prevalent in women, slender individuals, and those in academic professions.
  • Associated ocular findings include stiffer retinal vessels, decreased ocular blood flow autoregulation, and increased risk factors for normal tension glaucoma.

Conclusions:

  • Flammer syndrome is a distinct clinical entity with implications for vascular health and ocular diseases.
  • Further research is needed for precise definition, diagnosis, and risk assessment.
  • Personalized treatment strategies for Flammer syndrome and associated conditions are anticipated.