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Complex partial status epilepticus associated with cyclosporin A therapy.
R E Appleton1, K Farrell, P Teal
1Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Journal of Neurology, Neurosurgery, and Psychiatry
|September 1, 1989
Summary
Cyclosporin A (CyA) can cause neurotoxicity. Two patients on CyA experienced complex partial status epilepticus (CPSE) presenting as behavioral changes and stupor, highlighting the need for EEG in CyA-induced encephalopathy.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Neurology
Background:
- Cyclosporin A (CyA) is an immunosuppressant with known neurotoxic potential.
- Neurotoxicity from CyA can manifest as seizures, encephalopathy, and coma.
- Early recognition of CyA-induced neurological complications is crucial for patient management.
Observation:
- Two patients receiving CyA presented with altered behavior, stupor, and focal motor activity.
- Both patients were diagnosed with complex partial status epilepticus (CPSE).
- These symptoms suggest CPSE as a potential manifestation of CyA neurotoxicity.
Findings:
- Abnormal behavior and stupor in patients on CyA may indicate CPSE.
- Electroencephalography (EEG) is vital for diagnosing CPSE in this context.
- Prompt diagnosis can guide appropriate treatment adjustments.
Implications:
- Clinicians should consider CPSE in patients on CyA exhibiting neurological changes.
- Implementing EEG monitoring during altered mental status in CyA users is recommended.
- This underscores the importance of vigilant neurological monitoring for patients on immunosuppressive therapy.